Adenosine 5′-[γ-thio]triphosphate tetralithium salt

• 产品号: A1388
• CAS号: 93839-89-5
• 分子式: C10H12Li4N5O12P3S
• 分子量: 546.978863
• 纯 度: ≥75%

产品别名

• 标题: Adenosine 5′-[γ-thio]triphosphate tetralithium salt
• IUPAC标准名: tetralithium(1+) ion [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[dioxido(sulfanylidene)-λ^5-phosphanyl phosphonato]oxy}phosphonate
• IUPAC传统名: tetralithium(1+) ion [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [dioxido(sulfanylidene)-λ^5-phosphanyl phosphonato]oxyphosphonate
• 别名: Ado-5′-PPP[S]; ATP-γ-S; Adenosine 5′-(3-thiotriphosphate) tetralithium salt

产品登记号

• Beilstein号: 6265083
• MDL号: MFCD00077293
• EC号: 298-862-8
• PubChem SID: 24890536
• CAS号: 93839-89-5

产品性质

• 纯度: ≥75%
• 运输包装: dry ice
• 外观: white powder
• 溶解度: H2O: soluble25 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases.
Other Notes
Non-hydrolyzable ATP analog
Application
Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca2+-activated K+ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.