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链霉素 硫酸盐

产品号 S1277 公司名称 Sigma Aldrich
CAS号 3810-74-0 公司网站 http://www.sigmaaldrich.com
分子式 C42H84N14O36S3 电 话 1-800-521-8956
分子量 1457.38356 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 130846

产品价格信息

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产品别名

标题
Streptomycin sulfate salt
IUPAC标准名
bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
IUPAC传统名
bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)

产品登记号

PubChem SID 24899470
CAS号 3810-74-0
Beilstein号 3894995
MDL号 MFCD00037023
EC号 223-286-0

产品性质

药效 ≥720 I.U. per mg
适用性 suitable for mouse embryo cell culture
外观 powder
GHS危险品标识 GHS07
GHS危险品标识 GHS08
GHS警示词 Warning
GHS危险声明 H302-H361
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
个人保护装置 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示性声明 P281
危险公开号 63-22
RTECS编号 WK4990000
安全公开号 36/37
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Application
Recommended for use in embryo culture at 50 mg/L. Stock solutions should be sterile-filtered and stored at 2-8 °C for up to a month or at -20 °C for extended periods. Solutions are stable at 37 °C for 3 days. Use to inhibit bacterial protein synthesis at the level of initiation. Use to study mechanisms of streptomycin resistance. Use together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.

参考文献