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3810-74-0 分子结构
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bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)

ChemBase编号:130846
分子式:C42H84N14O36S3
平均质量:1457.38356
单一同位素质量:1456.43347808
SMILES和InChIs

SMILES:
C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)NC(=N)N)O)NC(=N)N)O[C@H]1[C@H]([C@@H]([C@H]([C@@H](O1)CO)O)O)NC)(C=O)O.C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)NC(=N)N)O)NC(=N)N)O[C@H]1[C@H]([C@@H]([C@H]([C@@H](O1)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
Canonical SMILES:
OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OC[C@@H]1O[C@@H](O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@H]([C@@H]([C@H]3NC(=N)N)O)NC(=N)N)O[C@H]([C@]2(O)C=O)C)[C@H]([C@@H]([C@H]1O)O)NC.OC[C@@H]1O[C@@H](O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@H]([C@@H]([C@H]3NC(=N)N)O)NC(=N)N)O[C@H]([C@]2(O)C=O)C)[C@H]([C@@H]([C@H]1O)O)NC
InChI:
InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
InChIKey:
QTENRWWVYAAPBI-YZTFXSNBSA-N

引用这个纪录

CBID:130846 http://www.chembase.cn/molecule-130846.html

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名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
IUPAC传统名
bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
别名
链霉素 溶液
链霉素 硫酸盐
链霉素倍半硫酸盐
硫酸链霉素
Streptomycin solution
Streptomycin sulfate salt
Streptomycin sesquisulfate hydrate
Streptomycini sulfas
CAS号
3810-74-0
3810-74-0(anhydrous)
EC号
231-791-2
223-286-0
MDL号
MFCD00037023
Beilstein号
3894995
PubChem SID
24899525
24888475
24899445
24899828
24899705
162225124
24899470
24870421
PubChem CID
6419957

理论计算性质

理论计算性质

JChem
Acid pKa 10.877018  质子受体 19 
质子供体 14  LogD (pH = 5.5) -13.912841 
LogD (pH = 7.4) -12.161263  Log P -7.651423 
摩尔折射率 149.4707 cm3 极化性 52.500404 Å3
极化表面积 331.43 Å2 可自由旋转的化学键 18 
里宾斯基五规则 false 

分子性质

分子性质

理化性质 安全信息 产品相关信息 生物活性(PubChem)
溶解度
H2O: soluble0.1 g/mL, clear expand 查看数据来源
外观
powder expand 查看数据来源
white to off-white powder expand 查看数据来源
RTECS编号
WK4990000 expand 查看数据来源
欧盟危险性物质标志
有害性(Harmful) 有害性(Harmful) (Xn) expand 查看数据来源
MSDS下载
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
德国WGK号
3 expand 查看数据来源
危险公开号
22 expand 查看数据来源
63-22 expand 查看数据来源
安全公开号
36/37 expand 查看数据来源
GHS危险品标识
GHS07 expand 查看数据来源
GHS08 expand 查看数据来源
GHS警示词
Warning expand 查看数据来源
GHS危险声明
H302 expand 查看数据来源
H302-H361 expand 查看数据来源
GHS警示性声明
P281 expand 查看数据来源
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves expand 查看数据来源
Eyeshields, Gloves expand 查看数据来源
保存温度
2-8°C expand 查看数据来源
纯度
~95% (T) expand 查看数据来源
浓度
~1 mg/mL in 1 mM EDTA expand 查看数据来源
级别
analytical standard expand 查看数据来源
Biotechnology Performance Certified expand 查看数据来源
Ph Eur expand 查看数据来源
VETRANAL™, analytical standard expand 查看数据来源
药效
≥720 I.U. per mg expand 查看数据来源
≥720 I.U. per mg (dried basis) expand 查看数据来源
适用性
cell culture tested expand 查看数据来源
plant cell culture tested expand 查看数据来源
suitable for cell culture expand 查看数据来源
suitable for mouse embryo cell culture expand 查看数据来源
杂质
endotoxin, tested expand 查看数据来源
无菌消毒
γ-irradiated expand 查看数据来源
干燥失重
≤5% loss on drying expand 查看数据来源
Mol. Weight
calculated mol wt 1457.38 ((C21H39N7O12)2 ?3H2O4S) expand 查看数据来源
线性分子式
C21H39N7O12 · 1.5 H2SO4 expand 查看数据来源
Empirical Formula (Hill Notation)
C21H39N7O12 · 1.5H2O4S · xH2O expand 查看数据来源
C21H39N7O12 · 1.5H2SO4 expand 查看数据来源

详细说明

详细说明

Sigma Aldrich Sigma Aldrich
Sigma Aldrich -  S0774 external link
Application
Used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Sigma Aldrich -  S1277 external link
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Application
Recommended for use in embryo culture at 50 mg/L. Stock solutions should be sterile-filtered and stored at 2-8 °C for up to a month or at -20 °C for extended periods. Solutions are stable at 37 °C for 3 days. Use to inhibit bacterial protein synthesis at the level of initiation. Use to study mechanisms of streptomycin resistance. Use together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.
Sigma Aldrich -  S1567 external link
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Sigma Aldrich -  S9137 external link
Application
建议以 100mg/L 的量用于细胞培养应用。储存液应经过无菌过滤,在 2-8°C 下保存最多一个月或在 -20°C 下长期保存。溶液在 37°C 下可稳定 3 天。
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Sigma Aldrich -  46754 external link
法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC
Sigma Aldrich -  S6501 external link
Application
Used to inhibit bacterial protein synthesis at the level of initiation inhibition.
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Sigma Aldrich -  85880 external link
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Other Notes
在蛋白质合成中抑制启动并导致 mRNA 的误读1;在 E. coli2 中克隆和表达抗生物素蛋白时移除 DNA
Sigma Aldrich -  85884 external link
Application
Used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Sigma Aldrich -  S2522 external link
Application
建议以 25-50μg/ml 的量用于分子生物学应用。
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Reconstitution
直接在样品瓶中用无菌水 (25-20mg/ml) 制备储存液。储存液应在 -20°C 下保存。在 37°C 下可稳定 3 天。

参考文献

参考文献

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专利

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