N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin_分子结构_CAS_201608-14-2)

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N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin
产品号	A0466	公司名称	Sigma Aldrich
CAS号	201608-14-2	公司网站	http://www.sigmaaldrich.com
分子式	C30H34F3N5O13	电话	1-800-521-8956
分子量	729.6118696	传真
纯度	≥90% (HPLC)	电子邮件
保存		Chembase数据库ID: 106349

产品价格信息

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产品别名

标题

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin

IUPAC标准名

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

IUPAC传统名

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

别名

Ac-DEVD-AFC

产品登记号

CAS号	201608-14-2
MDL号	MFCD01310970

产品性质

纯度	≥90% (HPLC)
相关基因信息	human ... CASP3(836)
外观	white powder
溶解度	H2O: soluble1 mg/mL
个人保护装置	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度	-20°C
德国WGK号	3

产品详细信息

详细说明 (English)

Amino Acid Sequence
NAc-Asp-Glu-Val-Asp-AFC
Biochem/physiol Actions
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).