8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt

• 产品号: C3912
• CAS号: 93882-12-3
• 分子式: C16H14ClN5NaO6PS
• 分子量: 493.793791
• 纯 度: ≥97.0% (HPLC)

产品别名

• 标题: 8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt
• IUPAC标准名: sodium (4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• IUPAC传统名: sodium (4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]purin-9-yl}-7-hydroxy-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• 别名: pCPT-cAMP

产品登记号

• PubChem SID: 24278024
• CAS号: 93882-12-3
• MDL号: MFCD00057683
• EC号: 299-413-9

产品性质

• 纯度: ≥97.0% (HPLC)
• 相关基因信息: human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
• 外观: white powder
• 溶解度: H2O: soluble25 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Membrane permeable cAMP analog. Used as a selective activator of cAMP dependent protein kinase (PKA). Inhibits cGMP-dependent phosphodiesterase and, at higher concentrations, inhibits cAMP-dependent phosphodiesterase. Inhibits phosphoinositide hydrolysis and secretion stimulated by n-formyl-Met-Leu-Phe but not platelet-activating factor in leukocytes. Renders HL-60 cells more resistant to NO-induced DNA damage.