Kanamycin 二硫酸盐 来源于卡那霉素链霉菌

• 产品号: K1876
• CAS号: 64013-70-3
• 分子式: C18H40N4O19S2
• 分子量: 680.6556

产品别名

• 标题: Kanamycin disulfate salt from Streptomyces kanamyceticus
• IUPAC标准名: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol; bis(sulfuric acid)
• IUPAC传统名: kanamycin; bis(sulfuric acid)
• 别名: Kanamycin 硫酸氢盐; Kanamycin A

产品登记号

• MDL号: MFCD00143916
• CAS号: 64013-70-3

产品性质

• 杂质: ≤4% Kanamycin B
• 药效: ~650 μg per mg
• GHS警示词: Danger
• GHS危险声明: H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 61
• 安全公开号: 53-45
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Preparation Note
Kanamycin acid sulfate is prepared by solubilizing kanamycin sulfate in dilute sulfuric acid and drying. The sulfate content is approximately 25%.
Application
Aminoglycoside-antibiotic with broad antibacterial spectrum, (including mycobacteria, many gram-positive and most gram-negative organisms); Additive in culture media for the isolation of group D Streptococci on Kanamycin Esculin Azide Agar (Mossel et al.) or for selection of transformed plant cells containing the neomycin phosphotransferase (for kanamycin resistance); on a kanamycin-medium1,2. Kanamycin has been used for electrophysiological recordings of outer hair cells and inner hair cells3. It is used to inhibit shoot regeneration from Siberian Elmleaf explants4.
Biochem/physiol Actions
Kanamycin inhibits shoot regeneration of Siberian Elm leaf explants4. Kanamycin is an aminoglycoside antibiotic. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasm.