Clindamycin 2-phosphate

• 产品号: C6427
• CAS号: 24729-96-2
• 分子式: C18H34ClN2O8PS
• 分子量: 504.962921

产品别名

• 标题: Clindamycin 2-phosphate
• IUPAC标准名: {[(2R,3R,4S,5R)-6-[(2S)-2-chloro-1-{[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]formamido}propyl]-4,5-dihydroxy-2-(methylsulfanyl)oxan-3-yl]oxy}phosphonic acid
• IUPAC传统名: [(2R,3R,4S,5R)-6-[(2S)-2-chloro-1-{[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]formamido}propyl]-4,5-dihydroxy-2-(methylsulfanyl)oxan-3-yl]oxyphosphonic acid
• 别名: Clindamycin 2-dihydrogen phosphate

产品登记号

• PubChem SID: 24892866
• MDL号: MFCD07793328
• CAS号: 24729-96-2
• EC号: 246-433-0

产品性质

• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• RTECS编号: GF2625000
• 安全公开号: 36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. 2. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Other Notes
Antibacterial and antiprotozoal antibiotic of the licosamide class.
Application
Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines 1, Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase 2.