Methoctramine hydrate

• 产品号: M105
• CAS号: 104807-46-7(anhydrous)
• 分子式: C72H130Cl4N8O5
• 分子量: 1329.6652
• 纯 度: ≥97% (NMR)

产品别名

• 标题: Methoctramine hydrate
• IUPAC标准名: bis(1,26-bis(2-methoxyphenyl)-2,9,18,25-tetraazahexacosane) hydrate tetrahydrochloride
• IUPAC传统名: bis(1,26-bis(2-methoxyphenyl)-2,9,18,25-tetraazahexacosane) hydrate tetrahydrochloride
• 别名: N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate; Methoctramine tetrahydrochloride hydrate

产品登记号

• MDL号: MFCD11045942
• CAS号: 104807-46-7(anhydrous)
• PubChem SID: 24277850

产品性质

• 纯度: ≥97% (NMR)
• 相关基因信息: human ... CHRM2(1129)
• 外观: white solid
• 溶解度: H2O: >20 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. The increase in calcium and arachidonic acid release were attenuated by the M2 receptor antagonist methoctramine, but not by the M3 receptor antagonist p-fluoro-hexahydro siladifenidol.