L-733,060 hydrochloride

• 产品号: L137
• CAS号: 148687-76-7
• 分子式: C20H20ClF6NO
• 分子量: 439.8223192
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: L-733,060 hydrochloride
• IUPAC标准名: (2R,3R)-3-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-2-phenylpiperidine hydrochloride
• IUPAC传统名: (2R,3R)-3-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-2-phenylpiperidine hydrochloride
• 别名: (2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride

产品登记号

• PubChem SID: 24278530
• MDL号: MFCD06798982
• CAS号: 148687-76-7

产品性质

• 纯度: ≥98% (HPLC)
• 相关基因信息: human ... TACR1(6869)
• 外观: white solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Legal Information
Manufactured and sold under license from Merck, Sharp and Dohme Ltd.
Biochem/physiol Actions
Non-peptide NK1 tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse. Micromolar concentrations of L-733,060 inhibit the growth of human gastric and colon adenocarcinomas.in a dose-dependent manner, eventually leading to apoptosis in both cell lines.1