Ac-Asp-Glu-Val-Asp-7-Amino-4-Methylcoumarin

• 产品号: 03AMC138
• CAS号: 169332-61-0
• 分子式: C30H37N5O13
• 分子量: 675.64048

产品别名

• 标题: Ac-Asp-Glu-Val-Asp-7-Amino-4-Methylcoumarin
• IUPAC标准名: (4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid
• IUPAC传统名: (4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-[(4-methyl-2-oxochromen-7-yl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid
• 别名: Ac-DEVD-AMC; Ac-Asp-Glu-Val-Asp-AMC

产品登记号

• CAS号: 169332-61-0

产品详细信息

详细说明 (English)

A fluorogenic substrate for Caspase-3 (CPP32, YAMA). Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 μM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
Excitation max.: 365-380 nm, Emission max.: 430-460 nm

参考文献

• Thornberry, N.A. et al., Science, 281:1312 (1998).
• Nicholson, D.W. et al., Nature, 376:37 (1995).
• Hermission, M., et al. 2000. Oncogene 19, 2338.