Ac-Ile-Glu-Thr-Asp-Aldehyde

• 产品号: 03AL012
• 分子式: C21H34N4O10
• 分子量: 502.51546

产品别名

• 标题: Ac-Ile-Glu-Thr-Asp-Aldehyde
• IUPAC标准名: (4S)-4-{[(1S,2R)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid
• IUPAC传统名: (4S)-4-{[(1S,2R)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid
• 别名: Ac-IETD-CHO; Ac-Ile-Glu-Thr-Asp-CHO

产品详细信息

详细说明 (English)

A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).

参考文献

• Thornberry, N.A. et al., Science, 281:1312 (1998).
• Gao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
• Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
• Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.