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L-Arginine

产品号 DB00125 公司名称 DrugBank
CAS号 74-79-3 公司网站 http://www.ualberta.ca/
分子式 C6H14N4O2 电 话 (780) 492-3111
分子量 174.20096 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 11

产品价格信息

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产品别名

标题
L-Arginine
IUPAC标准名
(2S)-2-amino-5-carbamimidamidopentanoic acid
IUPAC传统名
L-arginine
商标名
R-Gene 10 (Pharmacia Corp.)
Levargin
Minophagen A
Argivene
Argamine
Detoxargin
别名
Arginine
(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid
2-Amino-5-guanidinovaleric acid
L-(+)-Arginine
L-a-Amino-d-guanidinovaleric acid
L-Arg

产品登记号

CAS号 74-79-3
PubChem CID 6322
PubChem SID 46507180

产品性质

疏水性(logP) -3.6
溶解度 182 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description An essential amino acid that is physiologically active in the L-form. [PubChem]
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology Studies have shown that is has improved immune responses to bacteria, viruses and tumor cells; promotes wound healing and regeneration of the liver; causes the release of growth hormones; considered crucial for optimal muscle growth and tissue repair.
Toxicity Oral supplementation with L-arginine at doses up to 15 grams daily are generally well tolerated. The most common adverse reactions of higher doses from 15 to 30 grams daily are nausea, abdominal cramps and diarrhea. Some may experience these symptoms at lower doses.
Affected Organisms
Humans and other mammals
Biotransformation Some metabolism of L-arginine takes place in the enterocytes. L-arginine not metabolized in the enterocytes enters the portal circulation from whence it is transported to the liver, where again some portion of the amino acid is metabolized.
Absorption Absorbed from the lumen of the small intestine into the enterocytes. Absorption is efficient and occurs by an active transport mechanism.
References
Morris SM Jr: Enzymes of arginine metabolism. J Nutr. 2004 Oct;134(10 Suppl):2743S-2747S; discussion 2765S-2767S. [Pubmed]
Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith G: L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006 Jan 4;295(1):58-64. [Pubmed]
Alba-Roth J, Muller OA, Schopohl J, von Werder K: Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. [Pubmed]
External Links
Wikipedia
PDRhealth
Drugs.com

参考文献

  • Morris SM Jr: Enzymes of arginine metabolism. J Nutr. 2004 Oct;134(10 Suppl):2743S-2747S; discussion 2765S-2767S. Pubmed
  • Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith G: L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006 Jan 4;295(1):58-64. Pubmed
  • Alba-Roth J, Muller OA, Schopohl J, von Werder K: Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. Pubmed