tetramethylazanium chloride

• ChemBase编号: 77906
• 分子式: C4H12ClN
• 平均质量: 109.59778
• 单一同位素质量: 109.06582707
• SMILES: [N+](C)(C)(C)C.[Cl-]
• Canonical SMILES: C[N+](C)(C)C.[Cl-]
• InChI: InChI=1S/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1
• InChIKey: OKIZCWYLBDKLSU-UHFFFAOYSA-M

名称和登记号

名称

• IUPAC标准名: tetramethylazanium chloride
• IUPAC传统名: tetramethylammonium ion chloride; tetramethylammonium chloride
• 别名: 四甲基氯化铵; 四甲基氯化铵 溶液; TMA; Tetramethylammonium chloride; Tetramethylammonium chloride solution; Tetramethylammonium chloride; Tetramethylammonium chloride; N,N,N-Trimethyl methanaminium chloride; Tetramine chloride; USAF AN-8

登记号

• CAS号: 75-57-0
• EC号: 200-880-8
• MDL号: MFCD00011628
• Beilstein号: 2496575; 3911201
• PubChem SID: 24900143; 162042749; 24888937; 24900000; 24886658; 24888936
• PubChem CID: 6379
• 维基百科标题: Tetramethylammonium_chloride

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): -3.9721673
• LogD (pH = 7.4): -3.9721673
• Log P: -3.9721673
• 摩尔折射率: 35.9017 cm^3
• 极化性: 9.572162 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: H2O: soluble6 M at 20 °C, clear, colorless; methanol: soluble0.1 g/mL, clear, colorless; Soluble in water
• 外观: White crystals
• 熔点: > 300°C; >300 °C(lit.); >300°C; >300°C; 425 °C (dec)
• 密度: 1.169; 1.17; 1.17 g/cm^3; 1.17 g/ml
• 紫外吸收波长: λ: 220 nm Amax: 0.05; λ: 230 nm Amax: 0.04; λ: 250 nm Amax: 0.03; λ: 260 nm Amax: 0.02; λ: 280 nm Amax: 0.02; λ: 500 nm Amax: 0.02

安全信息

• 保存条件: Room Temperature (15-30°C), Desiccate
• 保存注意事项: Hygroscopic; Toxic/Harmful/Irritant/Hygroscopic/Store under Argon
• RTECS编号: BS7700000
• 欧盟危险性物质标志: 有毒(Toxic) (T); 刺激性(Irritant) (Xi)
• 联合国危险货物编号: 2810; 2811; UN2811
• 德国WGK号: 1
• 联合国危险货物等级: 6.1
• 联合国危险货物包装类别(PG): 2; 3; II
• 澳大利亚Hazchem: 2XE
• 危险公开号: 21-25-36/37/38; R:25-36/37/38
• 安全公开号: 26-28-36/37-45; 26-36/37-45; S:20-26-46-36/37/39
• 欧盟危险货物分类: T2
• 欧盟危险识别号(EUHIN): 6.1B
• 美国ERG指导号: 154
• TSCA收录: 是
• GHS危险品标识: GHS06
• GHS警示词: Danger
• GHS危险声明: H300-H311-H315-H319-H335; H301 + H311-H315-H319-H335; H301-H311-H315-H319-H335
• GHS警示性声明: P261-P264-P280-P301 + P310-P305 + P351 + P338-P312; P261-P280-P301 + P310-P305 + P351 + P338-P312; P280H-P305+P351+P338-P309-P310
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter; Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• RID/ADR: UN 2810 6.1/PG 3; UN 2811 6.1/PG 2

产品相关信息

• 纯度: ~98%; ≥98%; ≥98.0% (AT); ≥99.0%; ≥99.0% (AT); 95+%; 97%, may cont. ca 3% silica as anticaking agent
• 浓度: 5 M
• 级别: for electrochemical analysis; for ion pair chromatography; for molecular biology; purum; reagent grade
• 适用性: corresponds to standard for filter test; corresponds to standard for RP gradient test
• 杂质: ≤2% water; DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• 痕量阳离子: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• 痕量阴离子: bromide (Br-): ≤500 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNase, RNase, none detected
• λ: 1 M in H2O; 10 % in H2O
• 产品线: BioUltra
• 线性分子式: (CH3)4N(Cl)

详细说明

MP Biomedicals - 02152113

Crystalline
Purity: ~98%

Sigma Aldrich - T3411

Application
四甲基铵结合富含 AT 的 DNA 聚合物，进而避免 AT 相对 GC 碱基对的优先熔解。以 18 兆欧水中 0.2μm 过滤溶液形式提供。

Sigma Aldrich - 87718

Other Notes
Hybridization of genomic DNA to AT-rich oligonucleotide probes1

Sigma Aldrich - 87719

General description
请访问 传感器应用门户网站 了解更多信息。

Sigma Aldrich - T19526

包装
100, 500 g in poly bottle
5 g in glass bottle

参考文献

• Thermally-stable phase-transfer catalyst (see Appendix 2) which has been used in nucleophilic displacement reactions of aryl nitro groups with KF in tetramethylene sulfone: J. Org. Chem., 56, 6406 (1991). A detailed study of the halex Cl ^- /F ^- exchange reaction of activated aryl chlorides, for example the conversion of 1,2-dichloro-4-nitrobenzene to 2-chloro-1-fluoro-4-nitrobenzene in DMSO at 120^oC showed tetramethylammonium chloride to be superior to other common phase-transfer catalysts. It was necessary to pre-dry the catalyst to <0.2% water to avoid competition from hydrolytic displacement: Chem. Commun., 297 (1996).
• Compare also Tetraphenylphosphonium bromide, A15860 and Tetraphenylphosphonium chloride, A10575.