2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate

• ChemBase编号: 177927
• 分子式: C12H13N3O8
• 平均质量: 327.24692
• 单一同位素质量: 327.07026439
• SMILES: C1CC(=O)N(C1=O)OC(=O)NCCC(=O)ON1C(=O)CCC1=O
• Canonical SMILES: O=C(ON1C(=O)CCC1=O)CCNC(=O)ON1C(=O)CCC1=O
• InChI: InChI=1S/C12H13N3O8/c16-7-1-2-8(17)14(7)22-11(20)5-6-13-12(21)23-15-9(18)3-4-10(15)19/h1-6H2,(H,13,21)
• InChIKey: JWOINKOELUJJOB-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate
• IUPAC传统名: 2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate
• 别名: N-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-β-alanine 2,5-Dioxo-1-pyrrolidinyl Ester; 1-[3-[[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]amino]-1-oxopropoxy]-2,5-pyrrolidinedione; N-[[N-[(Succinimidooxy)carbonyl]-β-alanyl]oxy]succinimide; N-Succinimidoxycarbonyl-β-alanine N-Succinimidyl Ester

登记号

• CAS号: 21994-89-8
• PubChem SID: 164233837
• PubChem CID: 5098607

理论计算性质

• Acid pKa: 13.394622
• 质子受体: 6
• 质子供体: 1
• LogD (pH = 5.5): -1.8790483
• LogD (pH = 7.4): -1.8790487
• Log P: -1.8790483
• 摩尔折射率: 68.1087 cm^3
• 极化性: 27.120058 Å^3
• 极化表面积: 139.39 Å^2
• 可自由旋转的化学键: 7
• 里宾斯基五规则: true

详细说明

Toronto Research Chemicals - S689840

A short, amino reactive homobifunctional crosslinking reagent. Crosslinking distance 8.3 Å. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react.

参考文献

• Gross, H., et al.: Tetrahedron, 24, 6935 (1968)
• Clark, R., et al.: J. Biol. Chem., 271, 21969 (1968)
• Guiotto, A., et al.: Bioorg. Med. Chem., 12, 5031 (1968)