2-(4-ethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1,4-dihydroquinazolin-2-yl]-1,4-dihydroquinazoline trihydrochloride

• ChemBase编号: 130884
• 分子式: C29H35Cl3N6O
• 平均质量: 589.9868
• 单一同位素质量: 588.19379281
• SMILES: CCOc1ccc(cc1)C1=NCc2cc(ccc2N1)C1=NCc2cc(ccc2N1)N1CCN(CC1)C.Cl.Cl.Cl
• Canonical SMILES: CCOc1ccc(cc1)C1=NCc2c(N1)ccc(c2)C1=NCc2c(N1)ccc(c2)N1CCN(CC1)C.Cl.Cl.Cl
• InChI: InChI=1S/C29H32N6O.3ClH/c1-3-36-25-8-4-20(5-9-25)28-30-18-22-16-21(6-10-26(22)32-28)29-31-19-23-17-24(7-11-27(23)33-29)35-14-12-34(2)13-15-35;;;/h4-11,16-17H,3,12-15,18-19H2,1-2H3,(H,30,32)(H,31,33);3*1H
• InChIKey: FYEVKHPLBHLWHK-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 2-(4-ethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1,4-dihydroquinazolin-2-yl]-1,4-dihydroquinazoline trihydrochloride
• IUPAC传统名: 2-(4-ethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1,4-dihydroquinazolin-2-yl]-1,4-dihydroquinazoline trihydrochloride
• 别名: 2′-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5′-bi-1H-benzimidazole trihydrochloride; HOE 33342; Hoechst 33342; bisBenzimide; bisBenzimide H 33342 trihydrochloride

登记号

• CAS号: 23491-52-3
• EC号: 245-691-1
• MDL号: MFCD00012678
• Beilstein号: 1234011
• PubChem SID: 24860048; 24891639; 162225162; 24859913; 24848717
• PubChem CID: 16211280

理论计算性质

• 质子受体: 7
• 质子供体: 2
• LogD (pH = 5.5): -1.1054447
• LogD (pH = 7.4): 2.9911063
• Log P: 4.286445
• 摩尔折射率: 149.8323 cm^3
• 极化性: 54.628204 Å^3
• 极化表面积: 64.49 Å^2
• 可自由旋转的化学键: 5
• 里宾斯基五规则: false

分子性质

理化性质

• 溶解度: H2O: soluble20 mg/mL; phosphate buffer: precipitates
• 荧光: λex 340 nm; λem 510 nm; λex 355 nm; λem 465 nm in TE buffer; DNA

安全信息

• RTECS编号: DT4200000
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C); 有害性(Harmful) (Xn)
• 德国WGK号: 3
• 危险公开号: 22-35-37; 22-37/38
• 安全公开号: 22-36/37; 26-36/37/39-45
• GHS危险品标识: GHS05; GHS07
• GHS警示词: Danger
• GHS危险声明: H302-H314-H335; H302-H315-H318-H335
• GHS警示性声明: P261-P280-P305 + P351 + P338; P261-P280-P305 + P351 + P338-P310
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 保存温度: -20°C; 2-8°C

产品相关信息

• 纯度: ≥97.0% (HPLC); ≥98% (HPLC and TLC)
• 级别: for fluorescence
• 适用性: suitable for fluorescence
• 产品质量级别: PREMIUM
• Empirical Formula (Hill Notation): C27H28N6O · 3HCl · xH2O

详细说明

Sigma Aldrich - 14533

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry.Excitation max. = 346 nmEmission max. = 460 nm
bisBenzimide H 33342 trihydrochloride can be used to study biochemicals and reagents, fluorescent probes, labels, particles and stains, luminescent compounds and detection and wavelength index. bisBenzimide H 33342 trihydrochloride, Hoechst 33342, has been used in a study to investigate the effects of inorganic and organic arsenic compounds on human T-lymphoblastoid leukemia cells. Hoechst 33342 has also been used in a study to examine the effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP.
Biochem/physiol Actions
Membrane-permeable, fluorescent DNA stains with low cytotoxicity that intercalate in A-T regions of DNA.
Other Notes
Suitable for vital DNA staining of a variety of cell types1,2; As a probe of membrane permeability in mammalian cells3

Sigma Aldrich - B2261

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry.Excitation max. = 346 nmEmission max. = 460 nm
Biochem/physiol Actions
Membrane-permeable, fluorescent DNA stains with low cytotoxicity that intercalate in A-T regions of DNA.
包装
1 g in glass bottle
100, 500 mg in glass bottle
25 mg in poly bottle

Sigma Aldrich - 33263

Application
Useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry.Excitation max. = 346 nmEmission max. = 460 nm
Biochem/physiol Actions
Membrane-permeable, fluorescent DNA stains with low cytotoxicity that intercalate in A-T regions of DNA.

Sigma Aldrich - 33270

Application
Useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry.Excitation max. = 346 nmEmission max. = 460 nm
Biochem/physiol Actions
Membrane-permeable, fluorescent DNA stains with low cytotoxicity that intercalate in A-T regions of DNA.