(2-hydroxyethyl)trimethylazanium chloride

• ChemBase编号: 102374
• 分子式: C5H14ClNO
• 平均质量: 139.62376
• 单一同位素质量: 139.07639175
• SMILES: [Cl-].C[N+](C)(C)CCO
• Canonical SMILES: OCC[N+](C)(C)C.[Cl-]
• InChI: InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
• InChIKey: SGMZJAMFUVOLNK-UHFFFAOYSA-M

名称和登记号

名称

• IUPAC标准名: (2-hydroxyethyl)trimethylazanium chloride
• IUPAC传统名: choline chloride
• 别名: (2-羟乙基)三甲基氯化铵; 氯化胆碱; (2-Hydroxyethyl)trimethylammonium chloride; CHOLINE CHLORIDE; 2-hydroxy-N,N,N-trimethylethanaminium chloride; (2-hydroxyethyl)trimethylazanium chloride; Trimethyl(2-hydroxyethyl)ammonium Chloride; Actiron CC 6; Bilineurin Chloride; Biocolina; Hepacholine; Lipotril; Neocolina; Paresan; 2-Hydroxy-N,N,N-trimethylethanaminium Chloride; Choline chloride

登记号

• CAS号: 67-48-1
• EC号: 200-655-4
• MDL号: MFCD00011721
• Beilstein号: 3563126
• 默克索引号: 142206
• PubChem SID: 24892968; 24856348; 162088424; 24892920; 24892445
• PubChem CID: 522265; 6209
• CHEBI ID: 133341
• CHEMBL: 282468
• Chemspider ID: 5974
• 美国药典/FDA物质标识码: 45I14D8O27
• 维基百科标题: Choline_chloride

理论计算性质

• Acid pKa: 13.968714
• 质子受体: 1
• 质子供体: 1
• LogD (pH = 5.5): -4.662269
• LogD (pH = 7.4): -4.6622667
• Log P: -4.662269
• 摩尔折射率: 42.194 cm^3
• 极化性: 12.021414 Å^3
• 极化表面积: 20.23 Å^2
• 可自由旋转的化学键: 2
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: DMSO; H2O: soluble1 M, clear, colorless; H2O: soluble50 mg/mL; Methanol; very soluble (>650 g/l) in water; Water
• 外观: powder; White Solid; White or deliquescent crystals
• 熔点: >300°C (dec.); 302 °C (decomposes); 302-305 °C (dec.)(lit.); ca 305°C dec.
• 密度: 1.1 g/cm^3 at 20 °C
• 蒸汽压: 10 hPa at 20 °C
• 紫外吸收波长: λ: 260 nm Amax: 0.015; λ: 280 nm Amax: 0.010
• 疏水性(logP): 0.0
• pH值: 5.0-7.5 (25 °C, 1 M in H2O)

安全信息

• 保存条件: Hygroscopic, Refrigerator, Under Inert Atmosphere; Room Temperature (15-30°C), Desiccate
• 保存注意事项: Hygroscopic
• RTECS编号: KH2975000
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 1
• 危险公开号: 36/37/38
• 安全公开号: 26-36; 26-37
• TSCA收录: 是
• GHS危险品标识: GHS07
• GHS警示词: Warning
• NFPA704:
  

  0

  2

  0
• GHS危险声明: H315-H319-H335; H315-H319-H335-H303
• GHS警示性声明: P261-P305 + P351 + P338; P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves

药理学性质

• 作用靶点: Others

产品相关信息

• 纯度: ≥97.0% (AT); ≥98%; ≥99%; ≥99.0% (AT); 95%; 98+%; 99%
• 级别: ReagentPlus®
• 成盐信息: Chloride; Cl-
• 适用性: suitable for cell culture; suitable for insect cell culture
• 杂质: insoluble matter, passes filter test
• 痕量阳离子: Al: ≤5 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• 痕量阴离子: sulfate (SO42-): ≤50 mg/kg
• λ: 1 M in H2O
• 产品线: BioUltra
• 线性分子式: (CH3)3N(Cl)CH2CH2OH

详细说明

MP Biomedicals - 05207255

MP Biomedicals Rare Chemical collection

MP Biomedicals - 02101386

Purity: 99%
Suitable for use as a substrate for choline acetyl transferase.

Sigma Aldrich - C7017

包装
10 mg in autosmp vl
5, 25, 100 g in glass bottle
Substrates
胆碱乙酰基转移酶底物
Biochem/physiol Actions
Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Sigma Aldrich - C1879

包装
1, 5 kg in poly drum
500 g in poly bottle
Substrates
胆碱乙酰基转移酶底物
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes 1.

Sigma Aldrich - C7527

Application
A source of methyl groups for methyl-transfer reactions.
Substrates
胆碱乙酰基转移酶底物
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes 1.

Sigma Aldrich - 26978

Biochem/physiol Actions
Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes 1.
Other Notes
Restores cholinergic, biochemical and pharmacological activities in striata of decorticated rats2
Sales restrictions may apply
Substrates
胆碱乙酰基转移酶底物

Sigma Aldrich - 239941

包装
50 g in glass bottle
Substrates
胆碱乙酰基转移酶底物
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes 1.
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - 26980

Substrates
胆碱乙酰基转移酶底物
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes 1.

Toronto Research Chemicals - C432650

Lipotropic.

参考文献

• Hartung, C., et al.: Toxicol. Appl. Pharmacol., 12, 486 (1968)
• Sitaram, N., et al.: Life Sci., et al.: 22, 1555 (1968)