| Item |
Information |
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Drug Groups
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approved |
|
Description
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A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. [PubChem] |
| Indication |
Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma. |
| Pharmacology |
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential. |
| Toxicity |
Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Hepatic. |
| Absorption |
Readily absorbed following oral administration. |
| Half Life |
28 ±8.3 hours in normal adults. |
| Protein Binding |
Very high (more than 90%) to serum proteins. |
| Elimination |
Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys. |
| External Links |
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