Trilostane

• 产品号: DB01108
• CAS号: 13647-35-3
• 分子式: C20H27NO3
• 分子量: 329.43328

产品别名

• 标题: Trilostane
• IUPAC标准名: (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile
• IUPAC传统名: trilostane
• 商标名: Desopan; Modrastane; Modrenal
• 别名: trilostane

产品登记号

• CAS号: 13647-35-3
• PubChem CID: 656583
• PubChem SID: 46507062

产品性质

• 疏水性(logP): 3

产品详细信息

详细说明 (English)

• Drug Groups: approved; withdrawn; investigational
• Description: Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994. [Wikipedia]
• Indication: Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
• Pharmacology: Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland. This product was withdrawn from the U.S. market in April 1994.
• Toxicity: Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Half Life: 8 hours.
• References: Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51. [Pubmed]
• External Links: Wikipedia

参考文献

• Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51. Pubmed