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Remikiren

产品号 DB00212 公司名称 DrugBank
CAS号 126222-34-2 公司网站 http://www.ualberta.ca/
分子式 C33H50N4O6S 电 话 (780) 492-3111
分子量 630.8383 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 97

产品价格信息

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产品别名

标题
Remikiren
IUPAC标准名
(2S)-2-[(2R)-2-benzyl-3-(2-methylpropane-2-sulfonyl)propanamido]-N-[(2R,3S,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(1H-imidazol-5-yl)propanamide
IUPAC传统名
(2S)-2-[(2R)-2-benzyl-3-(2-methylpropane-2-sulfonyl)propanamido]-N-[(2R,3S,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(3H-imidazol-4-yl)propanamide
别名
Ro 42-5892

产品登记号

PubChem CID 5462340
CAS号 126222-34-2
PubChem SID 46507286

产品性质

疏水性(logP) 3.9

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Remikiren is an orally active, high specificity renin inhibitor.
Indication For the treatment of hypertension and heart failure
Pharmacology Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension. No data are available on the renal effects of remikiren in humans. In patients with essential hypertension, a single oral dose of remikiren can induce a renal vasodilation, without affecting the GFR and despite a significant decrease in blood pressure. This systemic and renal hemodynamic response is more pronounced in case of a more activated renin-angiotensin system.
Affected Organisms
Humans and other mammals
Absorption Absorbed following oral administration.
Protein Binding 83%
References
Clozel JP, Fischli W: Discovery of remikiren as the first orally active renin inhibitor. Arzneimittelforschung. 1993 Feb;43(2A):260-2. [Pubmed]
Richter WF, Whitby BR, Chou RC: Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica. 1996 Mar;26(3):243-54. [Pubmed]
External Links
Wikipedia

参考文献

  • Clozel JP, Fischli W: Discovery of remikiren as the first orally active renin inhibitor. Arzneimittelforschung. 1993 Feb;43(2A):260-2. Pubmed
  • Richter WF, Whitby BR, Chou RC: Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica. 1996 Mar;26(3):243-54. Pubmed