| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. [PubChem] |
| Indication |
Used to produce controlled hypotension during surgical procedures and in hypertensive crises. |
| Pharmacology |
Pentolinium acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously. |
| Toxicity |
Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg. |
| Affected Organisms |
| • |
Humans and other mammals |
|