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Pilocarpine

产品号 DB01085 公司名称 DrugBank
CAS号 54-71-7 公司网站 http://www.ualberta.ca/
分子式 C11H16N2O2 电 话 (780) 492-3111
分子量 208.25694 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 956

产品价格信息

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产品别名

标题
Pilocarpine
IUPAC标准名
(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one
IUPAC传统名
pilocarpine
商标名
Ocusert Pilo
Ocusert Pilo-40
Isopto Carpine
Epicar
Akarpine
Isoptocarpine
Pilagan
Pilokarpol
Pilomiotin
Pilopine HS
Pilostat
Almocarpine
Ami-Pilo
Amistura P
Mi-Pilo
Mi-Pilo Ophth Sol
Miocarpine
Mistura P
Ocu-Carpine
Ocusert P 20
P.V. Carpine Liquifilm
Pilocar SMP
Pilocel
Piloptic-1
Piloptic-2
Piloptic-4
Piloptic-6
Pilovisc
Sno Pilo
Minims Pilocarpine
Ocusert Pilo-20
Pilocar
Pilocarpal
Pilocarpol
Piloptic-1/2
Piloptic-3
Salagen
Syncarpine
别名
Spersacarpine hydrochloride
Adsorbocarpine
Pilocarpine chloride
Pilokarpin
Beta-pilocarpine hydrochloride
Pilocarpine HCl
Pilocarpine hydrochloride
Pilocarpine monohydrochloride
Pilocarpine muriate
Spersacarpine
Pilokarpin monohydrochloride
Pilocarpin

产品登记号

PubChem SID 46507475
CAS号 54-71-7
PubChem CID 5910

产品性质

疏水性(logP) 1.1
溶解度 1000 mg/ml

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. [PubChem]
Indication For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Pharmacology Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall. Dose-related smooth muscle stimulation of the intestinal tract may cause increased tone, increased motility, spasm, and tenesmus. Bronchial smooth muscle tone may increase. The tone and motility of urinary tract, gallbladder, and biliary duct smooth muscle may be enhanced. Pilocarpine may have paradoxical effects on the cardiovascular system. The expected effect of a muscarinic agonist is vasodepression, but administration of pilocarpine may produce hypertension after a brief episode of hypotension. Bradycardia and tachycardia have both been reported with use of pilocarpine.
Affected Organisms
Humans and other mammals
Biotransformation Possibly occurs at the neuronal synapses and in the plasma
Absorption There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers
Half Life 0.76 hours
External Links
Wikipedia
RxList
Drugs.com

参考文献