| Item |
Information |
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Drug Groups
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approved |
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Description
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Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis. [Wikipedia] |
| Indication |
For the temporary relief of the signs and symptoms of allergic conjunctivitis. |
| Pharmacology |
Emedastine is a relatively selective H1-receptor antagonist. |
| Toxicity |
Somnolence and malaise have been reported following daily oral administration. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Two primary metabolites, 5-hydroxyemedastine and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. The 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide are also formed as minor metabolites. |
| Absorption |
Ophthalmic use of emedastine usually does not produce measurable plasma concentrations. |
| Half Life |
The elimination half-life of oral emedastine in plasma is 3-4 hours. |
| Elimination |
Approximately 44% of the oral dose is recovered in the urine over 24 hours with only 3.6% of the dose excreted as parent drug. Two primary metabolites, 5- and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. |
| External Links |
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