| Item |
Information |
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Drug Groups
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approved |
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Description
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Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. [Wikipedia] |
| Indication |
For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back. |
| Pharmacology |
Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. |
| Toxicity |
The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A. |
| Affected Organisms |
| • |
Humans and other mammals |
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| Biotransformation |
Metabolized mainly by O-demethylation, hydroxylation and conjugation, and excretion is primarily by the biliary route. |
| Absorption |
Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials |
| Elimination |
Excretion appears to be primarily by the biliary route. |
| References |
| • |
Rolewski SL: Clinical review: topical retinoids. Dermatol Nurs. 2003 Oct;15(5):447-50, 459-65.
[Pubmed]
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| External Links |
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