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Dihydrotachysterol

产品号 DB01070 公司名称 DrugBank
CAS号 67-96-9 公司网站 http://www.ualberta.ca/
分子式 C28H46O 电 话 (780) 492-3111
分子量 398.66424 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 941

产品价格信息

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产品别名

标题
Dihydrotachysterol
IUPAC标准名
(3Z)-3-{2-[(4E)-1-[(3E)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylcyclohexan-1-ol
IUPAC传统名
dihydrotachysterol
商标名
Parterol
DHT Intensol
Dichystrolum
Dygratyl
Antitanil
Calcamine
Dihydral
Hytakerol
Tachystin
别名
Vitamin D4
Dihydrotachysterol

产品登记号

CAS号 67-96-9

产品性质

疏水性(logP) 7.5

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem]
Indication Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
Pharmacology Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. Dihydrotachysterol also increases renal phosphate excretion.
Toxicity Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
Affected Organisms
Humans and other mammals
Protein Binding >99%
References
DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. [Pubmed]
Bosch R, Thijssen JH, Duursma SA: Action and metabolism of dihydrotachysterol2. J Steroid Biochem. 1987;27(4-6):829-36. [Pubmed]
Pierides AM: Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981 Apr;21(4):241-56. [Pubmed]
External Links
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参考文献

  • DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Pubmed
  • Bosch R, Thijssen JH, Duursma SA: Action and metabolism of dihydrotachysterol2. J Steroid Biochem. 1987;27(4-6):829-36. Pubmed
  • Pierides AM: Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981 Apr;21(4):241-56. Pubmed