Echothiophate

• 产品号: DB01057
• CAS号: 6736-03-4
• 分子式: C9H23NO3PS+
• 分子量: 256.322581

产品别名

• 标题: Echothiophate
• IUPAC标准名: diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate
• IUPAC传统名: echothiophate
• 商标名: Echodide; Phospholine Iodide
• 别名: Phospholine Iodide; Phospholine; Echothiophate Iodide

产品登记号

• PubChem SID: 46505944
• CAS号: 6736-03-4
• PubChem CID: 10547

产品性质

• 疏水性(logP): -2.25
• 溶解度: Soluble

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
• Indication: For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
• Pharmacology: Echothiophate Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
• Toxicity: Side effects include blurred vision or change in near or distant vision and eye pain.
• Affected Organisms: Humans and other mammals
• References: Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. [Pubmed] ; Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

参考文献

• Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. Pubmed
• Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. Pubmed