| Item |
Information |
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Drug Groups
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approved; nutraceutical |
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Description
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A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [PubChem] |
| Indication |
For nutritional supplementation, also for treating dietary shortage or imbalance |
| Pharmacology |
This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh). Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth. |
| Toxicity |
Oral rat LD50: 3400 mg/kg |
| Affected Organisms |
| • |
Humans and other mammals |
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| External Links |
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