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Hydroxyurea

产品号 DB01005 公司名称 DrugBank
CAS号 127-07-1 公司网站 http://www.ualberta.ca/
分子式 CH4N2O2 电 话 (780) 492-3111
分子量 76.05466 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 878

产品价格信息

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产品别名

标题
Hydroxyurea
IUPAC标准名
hydroxyurea
IUPAC传统名
hydroxyurea
商标名
Hydrea
Litaler
Biosupressin
Hydreia
Hydurea
Onco-Carbide
Ureaphil
Droxia
Hidrix
Hydura
Litalir
Oxyurea
别名
Idrossicarbamide [Dcit]
Hydroxycarbamide
HU
Carbamohydroxamic Acid
Carbamyl Hydroxamate
Hydroxycarbamine
Hydroxylurea
Carbamohydroximic Acid
Carbamoyl Oxime
Hydroxicarbamidum
Carbamohydroxyamic Acid
N-Carbamoylhydroxylamine
N-Hydroxyurea
Sterile Urea

产品登记号

CAS号 127-07-1
PubChem SID 46506927
PubChem CID 3657

产品性质

疏水性(logP) -1.6
溶解度 1E+006 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. [PubChem]
Indication For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Pharmacology Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Toxicity Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Teratogenicity: Teratogenic effects have occurred in experimental animals.Hydroxyurea use during a small number of human pregnancies has been reported. Adverse effects have not been observed in any of the exposed newborns.
Reproductive Effects: Adverse reproductive effects have occurred in experimental animals.
Mutagenicity: Mutagenic effects have occurred in experimental animals.Mutagenic effects have occurred in humans.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Well absorbed from the gastrointestinal tract.
Half Life 3-4 hours
Elimination Renal excretion is a pathway of elimination.
External Links
Wikipedia
RxList
Drugs.com

参考文献