Cromoglicate

• 产品号: DB01003
• CAS号: 16110-51-3
• 分子式: C23H16O11
• 分子量: 468.36654

产品别名

• 标题: Cromoglicate
• IUPAC标准名: 5-{3-[(2-carboxy-4-oxo-4H-chromen-6-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid
• IUPAC传统名: 5-{3-[(2-carboxy-4-oxochromen-6-yl)oxy]-2-hydroxypropoxy}-4-oxochromene-2-carboxylic acid
• 商标名: Nasmil; Children's Nasalcrom; Lomusol; Alerion; Opticrom; Allergocrom; Apo-Cromolyn; Fivent; Gen-Cromoglycate; Intal; Lomudal; Nalcrom; Vividrin; Aarane; Alercom; Cromolyn Nasal Solution; Cromoptic; Cromovet; Gastrocrom; Gastrofrenal; Inostral; Intal Inhaler; Intal Syncroner; Introl; Lomupren; Lomuspray; Nalcron; Nasalcrom; Opticron; Rynacrom; Sofro; Vistacrom; Colimune; Crolom; Irtan
• 别名: Acide Cromoglicique [INN-French]; Acido Cromoglicico [INN-Spanish]; Cromoglycic Acid; Acidum Cromoglicicum [INN-Latin]; Cromoglicic Acid; Cromolyn; Cromoglycate

产品登记号

• CAS号: 16110-51-3

产品性质

• 疏水性(logP): 1.6
• 溶解度: 210 mg/L

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. [PubChem]
• Indication: For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
• Pharmacology: Cromoglicate or cromolyn (USAN), a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Cromoglicate is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis.
• Toxicity: Symptoms of overdose include cough, nasal congestion, nausea, sneezing and wheezing.
• Affected Organisms: Humans and other mammals
• Absorption: 1%
• Half Life: 1.3 hours
• References: Heinke S, Szucs G, Norris A, Droogmans G, Nilius B: Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. [Pubmed]
• External Links: Wikipedia; RxList

参考文献

• Heinke S, Szucs G, Norris A, Droogmans G, Nilius B: Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. Pubmed