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Dipyridamole

产品号 DB00975 公司名称 DrugBank
CAS号 58-32-2 公司网站 http://www.ualberta.ca/
分子式 C24H40N8O4 电 话 (780) 492-3111
分子量 504.6256 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 850

产品价格信息

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产品别名

标题
Dipyridamole
IUPAC标准名
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
IUPAC传统名
dipyridamole
商标名
Corosan
Aggrenox
Peridamol
Agilease
Anginal
Apo-Dipyridamole Fc
Cardioflux
Cleridium 150
Coridil
Justpertin
Permiltin
Prandiol
Prandiol 75
RA 8
Stenocardil
Apo-Dipyridamole Sc
Apricor
Chilcolan
Cleridium
Coronarine
Coroxin
Curantyl
Dipyridan
IV Persantine
Kurantil
Natyl
Novo-Dipiradol
Persantin
Persantine
Piroan
Protangix
RA-8
Stenocardiol
Stimolcardio
Cardoxil
Coribon
Gulliostin
别名
Usaf Ge-12
Dipyridamine
Dypyridamol
Dipyudamine
Dipiridamol
Dipyridamol

产品登记号

PubChem SID 46506292
CAS号 58-32-2
PubChem CID 3108

产品性质

疏水性(logP) 1.5
溶解度 Slightly

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Indication For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
Pharmacology Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.
Toxicity Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6,000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)
Affected Organisms
Humans and other mammals
Biotransformation hepatic
Absorption 70%
Half Life 40 minutes
Protein Binding 99%
Elimination Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile.
Distribution * 1 to 2.5 L/kg
Clearance * 2.3-3.5 mL/min/kg
References
Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

参考文献

  • Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. Pubmed