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Phenprocoumon

产品号 DB00946 公司名称 DrugBank
CAS号 435-97-2 公司网站 http://www.ualberta.ca/
分子式 C18H16O3 电 话 (780) 492-3111
分子量 280.31784 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 822

产品价格信息

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产品别名

标题
Phenprocoumon
IUPAC标准名
2-hydroxy-3-(1-phenylpropyl)-4H-chromen-4-one
IUPAC传统名
phenprocumonum
商标名
Falithiom
Marcumar
Fencumar
Liquamar
Falithrom
Marcoumar
Marcuphen
别名
Phenprocoumarol
Fenprocumone [DCIT]
Phenprocoumarole
Phenprocoumone
Phenprocumone

产品登记号

CAS号 435-97-2

产品性质

疏水性(logP) 4.4
溶解度 12.9 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Coumarin derivative that acts as a long acting oral anticoagulant. [PubChem]
Indication Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
Pharmacology Phenprocoumon, a coumarin anticoagulant, thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as phenprocoumon have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae.
Toxicity 50=500 mg/kg. Symptoms of overdose includes suspected or overt abnormal bleeding (e.g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries).
Affected Organisms
Humans and other mammals
Biotransformation Phenprocoumon is stereoselectively metabolized by hepatic microsomal enzymes (cytochrome P-450) to inactive hydroxylated metabolites (predominant route) and by reductases to reduced metabolites. Cytochrome P450 2C9 is the principal form of human liver P-450 responsible for metabolism.
Absorption Bioavailability is close to 100%
Half Life 5-6 days
Protein Binding 99%
External Links
Wikipedia

参考文献