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Methantheline

产品号 DB00940 公司名称 DrugBank
CAS号 5818-17-7 公司网站 http://www.ualberta.ca/
分子式 C21H26BrNO3 电 话 (780) 492-3111
分子量 420.34004 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 816

产品价格信息

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产品别名

标题
Methantheline
IUPAC标准名
diethyl(methyl)[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium bromide
IUPAC传统名
methantheline bromide
商标名
Resobantin
Vagamin
Banthine
Frenogastrico
Asabaine
Dixamone Bromide
Doladene
Gastrin I
Gastrosedan
Metantyl
Metaxan
Methelina
Avagal
Banthin
Gastrin-1 Human
Gastron
Mantheline
Methanide
Ulcine
Ulcudexter
Vagantin
Xanteline
别名
Methanthelinum
Methanthine Bromide
Methantheline Bromide
Methanthelinium
Methanthelinium Bromide
MTB 51
Banthine Bromide

产品登记号

PubChem SID 46505807
CAS号 5818-17-7
PubChem CID 4097

产品性质

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Methantheline is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children).
Indication For the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
Pharmacology Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites.
Toxicity Symptoms of overdose: blurred vision (continuing) or changes in near vision, clumsiness or unsteadiness, confusion, convulsions, difficulty in breathing, muscle weakness (severe), or tiredness (severe), dizziness, drowsiness (severe), dryness of mouth, nose, or throat (severe), fast heartbeat, fever, hallucinations, slurred speech, unusual excitement, nervousness, restlessness, or irritability, unusual warmth, dryness, and flushing of skin.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic, by enzymatic hydrolysis.
Absorption Rapidly absorbed.

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