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Mesoridazine

产品号 DB00933 公司名称 DrugBank
CAS号 5588-33-0 公司网站 http://www.ualberta.ca/
分子式 C21H26N2OS2 电 话 (780) 492-3111
分子量 386.57394 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 809

产品价格信息

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产品别名

标题
Mesoridazine
IUPAC标准名
2-methanesulfinyl-10-[2-(1-methylpiperidin-2-yl)ethyl]-10H-phenothiazine
IUPAC传统名
mesoridazine
商标名
Serentil
Lidanil
Serentil Concentrate
Calodal
Lidanar
别名
Thioridazine Monosulfoxide Analog
TPS23
Thioridazine Thiomethyl Sulfoxide
Thioridazien Thiomethyl Sulfoxide
TPS-23

产品登记号

PubChem SID 46506724
CAS号 5588-33-0
PubChem CID 4078

产品性质

疏水性(logP) 3.9

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A phenothiazine antipsychotic with effects similar to chlorpromazine. [PubChem]
Indication Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
Pharmacology Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.
Toxicity Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
Affected Organisms
Humans and other mammals
Absorption Well absorbed from the gastrointestinal tract.
Half Life 24 to 48 hours
Protein Binding 4%
External Links
Wikipedia
RxList
Drugs.com

参考文献