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Biotin

产品号 DB00121 公司名称 DrugBank
CAS号 58-85-5 公司网站 http://www.ualberta.ca/
分子式 C10H16N2O3S 电 话 (780) 492-3111
分子量 244.31064 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 8

产品价格信息

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产品别名

标题
Biotin
IUPAC标准名
5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
IUPAC传统名
biotin
商标名
Biodermatin
Bioepiderm
Bios II
Factor S
Lutavit H2
Meribin
Rovimix H2
Biotin Forte
别名
(+)-Biotin
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid
cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid
Vitamin H
Vitamin B7
D(+)-Biotin
D-Biotin
Coenzyme R

产品登记号

CAS号 58-85-5
PubChem CID 171548
PubChem SID 46508694

产品性质

疏水性(logP) 0.5
溶解度 0.22 mg/mL at 25 oC [MERCK INDEX (1996)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem]
Indication For nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes.
Toxicity Prolonged skin contact may cause irritation.
Affected Organisms
Humans and other mammals
Absorption Systemic - approximately 50%
References
Holmberg A, Blomstergren A, Nord O, Lukacs M, Lundeberg J, Uhlen M: The biotin-streptavidin interaction can be reversibly broken using water at elevated temperatures. Electrophoresis. 2005 Feb;26(3):501-10. [Pubmed]
External Links
Wikipedia
PDRhealth
Drugs.com

参考文献

  • Holmberg A, Blomstergren A, Nord O, Lukacs M, Lundeberg J, Uhlen M: The biotin-streptavidin interaction can be reversibly broken using water at elevated temperatures. Electrophoresis. 2005 Feb;26(3):501-10. Pubmed