Spectinomycin

• 产品号: DB00919
• CAS号: 1695-77-8
• 分子式: C14H24N2O7
• 分子量: 332.34956

产品别名

• 标题: Spectinomycin
• IUPAC标准名: (1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.0^{3,8}]tetradecan-7-one
• IUPAC传统名: spectinomycin
• 商标名: Togamycin; Actinospectacin; Spectam; Trobicin
• 别名: Antibiotic 2233wp; Espectinomicina [INN-Spanish]; SCM; Actinospectacina [Italian]; Spectinomicina [Italian]; Spectinomycin Di HCl; Spectinomycin HCl/ Sulphate; Spectinomycine [INN-French]; Spectinomycinum [INN-Latin]

产品登记号

• PubChem CID: 15541
• PubChem SID: 46505032
• CAS号: 1695-77-8

产品性质

• 疏水性(logP): -2.3
• 溶解度: Easily soluble in cold water

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
• Indication: For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae.
• Pharmacology: Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.
• Toxicity: Acute oral toxicity (LD₅₀): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Rapidly and almost completely absorbed after intramuscular injection.
• Half Life: 1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute.
• Protein Binding: Not significant
• External Links: Wikipedia; RxList; Drugs.com