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Remifentanil

产品号 DB00899 公司名称 DrugBank
CAS号 132875-61-7 公司网站 http://www.ualberta.ca/
分子式 C20H28N2O5 电 话 (780) 492-3111
分子量 376.44672 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 775

产品价格信息

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产品别名

标题
Remifentanil
IUPAC标准名
methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
IUPAC传统名
remifentanil
商标名
Ultiva
别名
Remifentanyl

产品登记号

PubChem CID 60815
CAS号 132875-61-7
PubChem SID 46504538

产品性质

疏水性(logP) 1.4

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist. Hence, it causes a reduction in sympathetic nervous system tone, respiratory depression and analgesia.
Indication For use during the induction and maintenance of general anesthesia.
Pharmacology Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Remifentanil in humans has a rapid blood-brain equilibration half-time of 1 ± 1 minutes (mean ± SD) and a rapid onset of action.
Affected Organisms
Humans and other mammals
Biotransformation By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases.
Half Life 1-20 minutes
Protein Binding 70% (bound to plasma proteins)
Elimination Remifentanil is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes.
Distribution * 350 mL/kg
* 452 ± 144 mL/kg [neonates]
* 223 ± 30.6 mL/kg [adolescents]
Clearance * 40 mL/min/kg [young, healthy adults]
External Links
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参考文献