| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
Adrenergic beta-agonist used to control premature labor. [PubChem] |
| Indication |
For the treatment and prophylaxis of premature labour |
| Pharmacology |
Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions. |
| Toxicity |
LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV) |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Hepatic, by both the mother and fetus |
| Half Life |
1.7-2.6 hours |
| Protein Binding |
~56% |
| External Links |
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