Geniposide

• 产品号: S2411
• CAS号: 24512-63-8
• 分子式: C17H24O10
• 分子量: 388.36646
• 保 存: -20°C

产品别名

• 标题: Geniposide
• IUPAC标准名: methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate
• IUPAC传统名: geniposide

产品登记号

• CAS号: 24512-63-8

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cardiovascular Disease
Biological Activity:
Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis. Geniposide is one of the biologically active ingredients of gardenia fruit. Geniposide is widely used in multi-component injection in the treatment of cerebrovascular and cardiovascular diseases in China for its anti-thrombotic and anti-inflammatory effects. Geniposide exerts protective effects against hepatic steatosis in rats fed with a high fat diet; the underlying mechanism may be associated with its antioxidant actions or regulation of adipocytokine release and expression of peroxisome proliferator-activated receptor-α. Geniposide (10-20 μM) inhibited high glucose (33 mM)-induced adhesion of monocytes to HUVECs in a dose-dependent manner. Geniposide (5-40 μM) also inhibited high glucose-induced expression of VCAM-1 and E-selectin at the gene and protein levels. Furthermore, geniposide (5-20 mM) decreased reactive oxygen species production and prevented IkappaB degradation in the cytoplasm and NF-kappaB translocation from the cytoplasm to the nucleus in HUVECs. [1][2][3]References on Geniposide[1] J Zhejiang Univ Sci B., 2011 Feb, 12(2):143-8[2] J Pharm Pharmacol., 2011 Apr, 63(4):587-93[3] Acta Pharmacol Sin., 2010 Aug, 31(8):953-62

参考文献

• Ma T et al. J Pharm Pharmacol. 2011 Apr; 63(4):587-93.