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Sarpogrelate hydrochloride

产品号 S2019 公司名称 Selleck Chemicals
CAS号 135159-51-2 公司网站 http://www.selleckchem.com
分子式 C24H32ClNO6 电 话 (877) 796-6397
分子量 465.96698 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 73237

产品价格信息

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产品别名

标题
Sarpogrelate hydrochloride
IUPAC标准名
4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride
IUPAC传统名
sarpogrelate hydrochloride

产品登记号

CAS号 135159-51-2

产品性质

作用靶点 Serotonin receptor
成盐信息 hydrochloride
保存条件 -20°C

产品详细信息

详细说明 (English)
Biological Activity:
Sarpogrelate hydrochloride is a selective 5-HT2A receptor antagonist to 5-HT2A, 5-HT2C and 5-HT2B receptors with pKi of 8.52, 7.43 and 6.57, respectively.Sarpogrelate hydrochloride reveals selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Additionally, Sarpogrelate hydrochloride displays cardioprotective activity in vivo. [1] Sarpogrelate hydrochloride improves vascular function in patients with peripheral arterial disease. Sarpogrelate hydrochloride blocks serotonin-induced platelet aggregation, and has applications in the treatment of many diseases including diabetes mellitus, Buerger’s disease, Raynaud’s disease, coronary artery disease, angina pectoris, and atherosclerosis. [2]References on Sarpogrelate HCl[1] J Cardiovasc Pharmacol., 2007, 49(4):221-7[2] http://en.wikipedia.org/wiki/Sarpogrelate, ,

参考文献

  • Miyazaki M, et al. J Cardiovasc Pharmacol. 2007;49(4):221-7.