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Formoterol hemifumarate

产品号 S2020 公司名称 Selleck Chemicals
CAS号 43229-80-7 公司网站 http://www.selleckchem.com
分子式 C42H52N4O12 电 话 (877) 796-6397
分子量 804.88188 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 73232

产品价格信息

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产品别名

标题
Formoterol hemifumarate
IUPAC标准名
(2E)-but-2-enedioic acid; bis(N-{2-hydroxy-5-[(1S)-1-hydroxy-2-{[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]phenyl}formamide)
IUPAC传统名
bis(N-{2-hydroxy-5-[(1S)-1-hydroxy-2-{[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]phenyl}formamide); fumaric acid

产品登记号

CAS号 43229-80-7

产品性质

作用靶点 adrenergic receptor
成盐信息 fumarate
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cancer
Biological Activity:
Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively. Formoterol hemifumarate reveals 330-fold selectivity forβ2 over β1 receptors. Formoterol hemifumarate potently relaxes guinea pig trachea (pD2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol. [1] Formoterol hemifumarate works like other β2-agonists, causing bronchodilation by relaxing the smooth muscle in the airway so as to treat the exacerbation of asthma. The long duration of formoterol action occurs because the formoterol molecules initially diffuse into the plasma membrane of the lung cells, and then are slowly released back outside, where they can come into contact with β2 adrenergic receptors. [2]References on Formoterol hemifumarate[1] Life Sci. , 1993, 52(26):2145-60[2] http://en.wikipedia.org/wiki/Formoterol, ,

参考文献

  • http://en.wikipedia.org/wiki/Formoterol