Calcium levofolinate

• 产品号: S2588
• CAS号: 80433-71-2
• 分子式: C20H21CaN7O7
• 分子量: 511.50144
• 保 存: -20°C

产品别名

• 标题: Calcium levofolinate
• IUPAC标准名: calcium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate
• IUPAC传统名: calcium(2+) (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate
• 别名: Calcium Folinate

产品登记号

• CAS号: 80433-71-2

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cancer
Biological Activity:
Calcium levofolinate (Calcium Folinate) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. Calcium levofolinate (Calcium Folinate) is also used in synergistic combination with the chemotherapy agent 5-fluorouracil. Folinic acid is a 5-formyl derivative of tetrahydrofolic acid. Folinic acid is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. However, since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. [1]

参考文献

• http://en.wikipedia.org/wiki/Folinic_acid