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Carvedilol

产品号 S1831 公司名称 Selleck Chemicals
CAS号 72956-09-3 公司网站 http://www.selleckchem.com
分子式 C24H26N2O4 电 话 (877) 796-6397
分子量 406.47424 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 1007

产品价格信息

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产品别名

标题
Carvedilol
IUPAC标准名
[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine
IUPAC传统名
carvedilol
别名
Coreg
Dilatrend

产品登记号

CAS号 72956-09-3

产品性质

作用靶点 adrenergic receptor
成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Biological Activity:
Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation. [1] Norepinephrine stimulates the nerves that control the muscles of the heart by binding to the β1- and β2-adrenergic receptors. Carvedilol blocks the binding to those receptors, which both slows the heart rhythm and reduces the force of the heart’s pumping. This lowers blood pressure and reduces heart failure. Norepinephrine also binds to the α1-adrenergic receptors on blood vessels, causing them to constrict and raise blood pressure. Carvedilol blocks this binding to the α1-adrenergic receptors too, which also lowers blood pressure. [2]

参考文献

  • http://en.wikipedia.org/wiki/Carvedilol