Chondroitin sulfate

• 产品号: S2416
• CAS号: 9007-28-7
• 分子式: C16H30N2O14S
• 分子量: 506.4794
• 保 存: -20°C

产品别名

• 标题: Chondroitin sulfate

产品登记号

• CAS号: 9007-28-7

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Immunology
Biological Activity:
Chondroitin sulfate is a kind of sulfated glycosaminoglycan (GAG) which is composed of a chain of alternating sugars including N-acetylgalactosamine and glucuronic acid. As part of a proteoglycan, it is usually attached to some particular proteins. The chondroitin chain contains over one hundred individual sugars sulfated in different positions and quantities. Chondroitin sulfate plays an important role in the structural constituent of cartilage. And chondroitin sulfate produces much of its resistance to compression. Chondroitin sulfate has become a broadly used dietary supplement for treatment of osteoarthritis in comination with glucosamine. Chondroitin sulfate chains are unbranched polysaccharides of variable length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). Some GlcA residues are epimerized into L-iduronic acid (IdoA); the resulting disaccharide is then referred to as dermatan sulfate. Chondroitin’s functions depend largely on the properties of the overall proteoglycan of which it is a part. These functions can be widely divided into structural and regulatory functions. [1]

参考文献

• Gabay C et al. Arthritis Rheum. 2011 Sep 6.