Tiotropium Bromide

• 产品号: S2546
• CAS号: 136310-93-5
• 分子式: C19H22BrNO4S2
• 分子量: 472.41628
• 保 存: -20°C

产品别名

• 标题: Tiotropium Bromide
• IUPAC标准名: (1R,2R,4S,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium bromide
• IUPAC传统名: (1R,2R,4S,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium bromide
• 别名: BA 679BR; Tiopropium; Tiova; Spiriva

产品登记号

• CAS号: 136310-93-5

产品性质

• 作用靶点: Muscarinic receptor
• 成盐信息: Bromide
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Biological Activity:
Tiotropium Bromide(Spiriva, BA 679BR) is a synthetic quaternary ammonium antimuscarinic agent and is a muscarinic receptor antagonist.Although tiotropium Bromide(Spiriva, BA 679BR) does not display selectivity for specific muscarinic receptors, on topical application tiotropium Bromide(Spiriva, BA 679BR) acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands not to produce smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect. Tiotropium Bromide(Spiriva, BA 679BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide(Spiriva, BA 679BR) improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. [1][2]References on Tiotropium Bromide(Spiriva, BA 679BR)[] Circ J, 2006, 70: 1658 – 1660

参考文献

• Kato M et al. Circ J. 2006 Dec; 70(12):1658-60.