(R)-Bicalutamide

• 产品号: S2241
• CAS号: 113299-40-4
• 分子式: C18H14F4N2O4S
• 分子量: 430.3733728
• 保 存: -20°C

产品别名

• 标题: (R)-Bicalutamide
• IUPAC标准名: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorobenzenesulfonyl)-2-hydroxy-2-methylpropanamide
• IUPAC传统名: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorobenzenesulfonyl)-2-hydroxy-2-methylpropanamide

产品登记号

• CAS号: 113299-40-4

产品性质

• 作用靶点: Androgen Receptor
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Biological Activity:
(R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells. (R)-Bicalutamide possesses virtually all activities. (R)-Bicalutamide is the leading antiandrogen. (R)-Bicalutamide is used for the treatment of prostate cancer and breast cancer. (R)-Bicalutamide prevents the activation of the androgen receptor and subsequent upregulation of androgen responsive genes by androgenic hormones. In addition, (R)-bicalutamide accelerates the degradation of the androgen receptor. [1][2][3]References on (R)-Bicalutamide[] PNAS, April 26, 2005, 102:6201–6206[] THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277:26321–26326[] J Pharmacol Exp Ther, 2005 February, 312(2): 546–553

参考文献

• Masiello D et al. J Biol Chem. 2002 Jul 19; 277(29):26321-6.