Trospium chloride

• 产品号: S2549
• CAS号: 10405-02-4
• 分子式: C25H30ClNO3
• 分子量: 427.9636
• 保 存: -20°C

产品别名

• 标题: Trospium chloride
• IUPAC标准名: (1S,3R,5R)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8$l^{5}-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium chloride
• IUPAC传统名: trospium chloride
• 别名: Sanctura

产品登记号

• CAS号: 10405-02-4

产品性质

• 作用靶点: Muscarinic receptor
• 成盐信息: chloride
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Biological Activity:
Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride (Sanctura) is a quaternary ammonium compound. Trospium chloride (Sanctura), dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. In active-controlled trials, trospium chloride was at least equivalent to immediate-release formulations of oxybutynin and tolterodine in efficacy and tolerability. [1][2][3]References on Trospium chloride (Sanctura)[] Ann Pharmacother, 2009, 43:283-295[] Therapeutics and Clinical Risk Management, 2005, 1(2):157–166

参考文献

• Guay DR. Ther Clin Risk Manag. 2005 Jun; 1(2):157-67.