Clomipramine hydrochloride

• 产品号: S2541
• CAS号: 17321-77-6
• 分子式: C19H24Cl2N2
• 分子量: 351.31326
• 保 存: -20°C

产品别名

• 标题: Clomipramine hydrochloride
• IUPAC标准名: (3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine hydrochloride
• IUPAC传统名: clomipramine hydrochloride
• 别名: Anafranil

产品登记号

• CAS号: 17321-77-6

产品性质

• 作用靶点: Reuptake inhibitor
• 成盐信息: hydrochloride
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Biological Activity:
Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant. Clomipramine hydrochloride (Anafranil) is a norepinephrine-reuptake inhibitor and is an antiobsessional drug.Clomipramine hydrochloride (Anafranil) is an antagonist/inverse agonist at the following receptors: D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), α1-adrenergic receptor (Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM). [1][2][3]References on Clomipramine HCl (Anafranil)[1] JPET, 2001, 298:565–580[2] MOLECULAR PHARMACOLOGY, 1992, 43:320-327

参考文献

• Monsma FJ Jr et al. Mol Pharmacol. 1993 Mar; 43(3):320-7.