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Asaraldehyde

产品号 S2531 公司名称 Selleck Chemicals
CAS号 4460-86-0 公司网站 http://www.selleckchem.com
分子式 C10H12O4 电 话 (877) 796-6397
分子量 196.19988 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 73066

产品价格信息

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产品别名

标题
Asaraldehyde
IUPAC标准名
2,4,5-trimethoxybenzaldehyde
IUPAC传统名
2,4,5-trimethoxybenzaldehyde
别名
NSC 89299
Asarylaldehyde
Asaronaldehyde

产品登记号

CAS号 4460-86-0

产品性质

作用靶点 COX
成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cancer
Biological Activity:
Asaraldehyde (Asaronaldehyde) is a selective COX-2 inhibitor.Asaraldehyde (Asaronaldehyde) was found to be the most abundant constituent, but was totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, asaraldehyde (Asaronaldehyde) was produced in both cultured broths. Asaraldehyde (Asaronaldehyde) showed 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/ml. 2,4,5-trimethoxybenzaldehyde showed selectivity towards COX-2 enzyme inhibition at 100 µg/ml. The COX-2/COX-1 ratio for compound 1 was 17.68 at 100 µg/ml compared to solvent control. [1][2]References on Asaraldehyde (Asaronaldehyde)[1] Letters in Applied Microbiology, 2007, 44 :387–392[2] Phytother. Res, 2003, 17:976–979

参考文献

  • Momin RA et al. Phytother Res. 2003 Sep;17(8)