Research Area: Cardiovascular Disease
Biological Activity:
Rosiglitazone maleate (Avandia) is an anti-diabetic agent in the thiazolidinedione class of agents. Rosiglitazone maleate (Avandia) acts primarily by increasing insulin sensitivity. Rosiglitazone maleate (Avandia) improves glycemic control while reducing circulating insulin levels. Rosiglitazone is a member of the thiazolidinedione class of agents. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). Thiazolidinediones enter the cell, bind to the nuclear receptors, and affect the expression of DNA. Rosiglitazone maleate (Avandia) also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance. [1] |