Olopatadine hydrochloride

• 产品号: S2494
• CAS号: 140462-76-6
• 分子式: C21H24ClNO3
• 分子量: 373.87316
• 保 存: -20°C

产品别名

• 标题: Olopatadine hydrochloride
• IUPAC标准名: 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• IUPAC传统名: [(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• 别名: Allelock; Patanase; Opatanol; Pataday

产品登记号

• CAS号: 140462-76-6

产品性质

• 成盐信息: hydrochloride
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Immunology
Biological Activity:
Olopatadine hydrochloride(Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 µM for the release of histamine. Evaluation of the interaction of olopatadine with histamine receptors revealed a relatively high affinity for the H1 receptor (Ki = 31.6 nM, pKi = 7.5 ± 0.1) but lower affinities for H2 receptors (Ki = 100 µM, pKi = 4.0 ± 0.19) and H3 receptors (Ki = 79.4 µM, pKi = 4.1 ± 0.16,). The H1 selectivity of olopatadine was superior to that of other ocularly used anti-histamines studied, such as ketotifen, levocabastine, antazoline and pheniramine. [1][2]

参考文献

• Sharif NA et al. J Pharmacol Exp Ther. 1996 Sep