Nitrendipine

• 产品号: S2491
• CAS号: 39562-70-4
• 分子式: C18H20N2O6
• 分子量: 360.3612
• 保 存: -20°C

产品别名

• 标题: Nitrendipine
• IUPAC标准名: 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC传统名: nitrendipine

产品登记号

• CAS号: 39562-70-4

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cardiovascular Disease
Biological Activity:
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 µM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 µM), but not magnitude, in the presence of glibenclamide (0.5 µM). [1][2]References on Nitrendipine[1] http://en.wikipedia.org/wiki/Nitrendipine, , [2] DICP., 1990 Feb, 24(2):167-75.

参考文献

• Santiago TM et al. DICP. 1990 Feb;24(2):167-75.